Article: HLA Class II Antigens and Their Interactive Effect on Perinatal Mother-To-Child HIV-1 Transmission.
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Luo M; Embree J; Ramdahin S; Bielawny T; Laycock T; Tuff J; Haber D; Plummer M; Plummer FA
PLoS ONE, 2015
10.1371/journal.pone.0126068.t005
The influence of specific HLA class II phenotypes on perinatal HIV-1 transmission.
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| Mother |
| mother's class II Phenotype |
mothers have only HIV negative kid (n = 127) |
mothers have HIV positive kid (n = 106) |
p value (FDR) |
odds ratio (95%CI) |
| DPB1*55:01 |
2 (1.6%) |
8 (7.5%) |
0.027 (NS) |
5.1 (1.06-24.57) |
| DQB1*03:03 |
6 (4.7%) |
0 |
0.025 (NS) |
do not transmit |
| Children |
| Children's class II Phenotype |
HIV- |
HIV+ |
p value (FDR) |
odds ratio (95%CI) |
| (n = 187) |
(n = 112) |
| DPA1*04:01 |
4 (2.1%) |
8 (7.1%) |
0.036 (NS) |
3.519 (1.04-11.97) |
| DRB3 |
167 (89.3%) |
83 (74.1%) |
0.0006 (0.014) |
0.343 (0.183-0.642) |
Inferred neuron-electrophysiology data values
| Neuron Type |
Neuron Description |
Ephys Prop |
Extracted Value |
Standardized Value |
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